![]() Tofacitinib decreased mean lymphocyte counts and slightly increased mean haemoglobin levels in RA patients, with few patients experiencing anaemia.Ĭhanges in haematological parameters stabilized over 66 months in long-term extension studies in RA. Changes in haemoglobin levels, although associated with changes in ESR and CRP, were not associated with fatigue or vitality. Small changes in haematological parameters were seen with tofacitinib treatment, which stabilized over time in the LTE studies. FACIT-F and Short Form Health Survey-36 vitality scores were weakly correlated with haemoglobin levels.Ĭonclusion. Clinically meaningful reductions in haemoglobin levels (⩾3 g/dl from baseline or haemoglobin ⩽7 g/dl) occurred in <1.0% of patients in all treatment groups. Increased haemoglobin was associated with decreased ESR and CRP levels. ![]() Haemoglobin levels and neutrophil counts stabilized in the LTE studies, while lymphocyte count decreases stabilized at approximately month 48. In phase 3 studies, mean neutrophil and lymphocyte counts decreased and mean haemoglobin levels increased in all tofacitinib treatment groups. Fatigue and vitality were assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and Short Form Health Survey-36 vitality domain scores. Disease activity markers included CRP and ESR. ![]() ![]() Changes in neutrophil counts, lymphocyte counts and haemoglobin levels were analysed in patients with RA from six phase 3 randomized controlled trials (n = 4271) of tofacitinib 5 or 10 mg bd, placebo or active comparators of up to 24 months’ duration, and two long-term extension (LTE) studies ( n = 4858) of tofacitinib of up to 84 months’ duration. The aim of this analysis was to characterize changes in haematological parameters following tofacitinib treatment, and to compare changes in haemoglobin with markers of disease activity, fatigue and vitality. Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. ![]()
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